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BACKGROUND: : The efficacy of the combination of voriconazole and caspofungin when used as primary therapy for invasive aspergillosis in organ transplant recipients has not been defined. METHODS: : Transplant recipients who received voriconazole and caspofungin (n=40) as primary therapy for invasive aspergillosis (proven or probable) in a prospective multicenter study between 2003 and 2005 were compared to a control group comprising a cohort of consecutive transplant recipients between 1999...
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Synonyms North American histoplasmosis. Contrast with African histoplasmosis due to Histoplasma duboisii Definition Histoplasmosis refers to the condition caused by the infection with the dimorphic endemic fungi N/A(L):Histoplasma capsulatum var. capsulatum. This anamorphic fungus has a known sexual teleomorph that carries the name Ajellomyces capsulatus. The majority of acute cases of infection with this fungus follow a subclinical and benign course in normal hosts [2412]. However, a...
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Synonyms African histoplasmosis. Contrast with North American histoplasmosis due to Histoplasma capsulatum Definition and forms of the disease Histoplasmosis due to N/A(L):Histoplasma duboisii is a mycotic infection primarily involving cutaneous, liver, lung, lymphatic, subcutaneous, and bony tissues. Skin and bone are the most frequently invaded sites [454]. The etiologic agent grows as a large yeast within giant cells. It may also present with small cells that are typical of those seen in...
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Overview Oropharyngeal candidiasis (OPC) is the general term given to the oral infection caused by the yeast Candida. This condition is also often referred to informally as “thrush”. As we will discuss in detail in this section, OPC meets all the criteria to be considered an opportunistic infection. Whereas asymptomatic oral colonization may also occur, OPC implies the presence of signs and symptoms of infection. Epidemiology Candida spp. are part of the normal mouth flora in...
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Synonyms Cerebral chromomycosis, chromoblastomycosis (in part), chromomycosis (in part), cladosporiosis, phaeomycotic cyst, phaeosporotrichosis, subcutaneous mycotic cyst. Definition Phaeohyphomycosis consists of a group of mycotic infections characterized by the presence of dematiaceous (dark-walled) septate hyphae and sometimes yeast or a combination of both in tissue. The hyphae may be short to elongate, distorted or swollen (toruloid hyphae), regularly shaped, or any combination of the...
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Synonyms None Definition Sporotrichosis refers to the infection caused by the dimorphic fungus N/A(L):Sporothrix schenckii. The disease has been described worldwide, however it is more common in tropical and subtropical America [1898, 2251]. Sporotrichosis is acquired through direct inoculation into the skin and rarely via inhalation of conidia. As a consequence, the majority of cases are localized lesions affecting the skin and subcutaneous tissues with minimal if any systemic...
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Living with itWorking with itTreating it The Aspergillus website is a comprehensive resource providing detailed information about the fungus Aspergillus and the diseases it can cause, these are usually called aspergillosis. 25 years of service to the clinical and research communities across the world. This site is free to use and provides an encyclopaedia of ... Read more
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Establishing diagnosis of latent and active histoplasmosis is challenging. Interferon gamma-release assays (IGRAs) may provide evidence of latent and active infection. An enzyme-linked immunospot (ELISpot) assay was developed using yeast cell lysate (YCL) antigen prepared from a representative North American Histoplasma capsulatum strain. Assay parameters were optimized by measuring responses in healthy volunteers with and without Histoplasma infection. Assay performance as an aid for...
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Background Liver transplantation is increasing worldwide with underlying pathologies dominated by metabolic and alcoholic diseases in developed countries. Methods We provide a narrative review of invasive aspergillosis (IA) in liver transplant (LT) recipients. We searched PubMed and Google Scholar for references without language and time restrictions. Results The incidence of IA in LT recipients is low (1.8%), while mortality is high (∼50%). It occurs mainly early (<3 months) after LT. Some...
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Es una infección con los hongos Cryptococcus neoformans o Cryptococcus gattii.
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Cryptococcosis is infection with the fungi Cryptococcus neoformans or Cryptococcus gattii.
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Es una infección micótica de los pulmones. La enfermedad se solía llamar Pneumocystis carinii o neumonía por PC.
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Pneumocystis jiroveci pneumonia is a fungal infection of the lungs. The disease used to be called Pneumocystis carini or PCP pneumonia.
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Background Sulfamethoxazole-trimethoprim (SMX-TMP) is recommended first-line for Pneumocystis jirovecii pneumonia (PJP) prophylaxis in kidney transplant recipients. In cases of sulfa allergy or intolerance, our center utilizes dapsone 100 mg once weekly as alternative prophylaxis. As both agents have the potential to cause hematologic abnormalities, we sought to compare hematologic effect profiles of weekly dapsone versus SMX-TMP in kidney transplant recipients. Methods This retrospective,...
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Fatal Mold Infections after Transplantation
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