Results – TransplantID

American Society of Transplantation and Cellular Therapy Series: #8-Management and Prevention of Non-Aspergillus Molds in Hematopoietic Cell Transplantation Recipients

Douglas, A. P., Lamoth, F., John, T. M., … Kontoyiannis, D. P. - 2025 - Transplantation and Cellular Therapy, Official Publication of the American Society for Transplantation and Cellular Therapy, 31(4), 194–223

Adjunct Terbinafine in Patients With Leukemia and Invasive Fusariosis With Skin Lesions: Discordance Between Responses of Skin Lesions and Systemic Outcomes

Matsuo, T., Wurster, S., Jiang, Y., … Kontoyiannis, D. P. - 2024 - Open Forum Infectious Diseases, 11(2), ofae068

To theEditor—Invasive fusariosis (IF) is a severe opportunistic mold infection that often results in poor outcomes, especially for patients with hematological malignancies [1–4]. Skin involvement is the second most common manifestation of IF after pulmonary involvement [1–3]. While in vitro studies showed synergistic effects of the squalene epoxidase inhibitor terbinafine (TRB) when combined with triazoles [5] or liposomal amphotericin B (L-Amb) [6] against various fungal pathogens,...

Invasive fusariosis

Nucci, M., & Anaissie, E. - 2023 - Clinical Microbiology Reviews, e00159-22

SUMMARY Invasive fusariosis is a serious invasive fungal disease, affecting immunocompetent and, more frequently, immunocompromised patients. Localized disease is the typical clinical form in immunocompetent patients. Immunocompromised hosts at elevated risk of developing invasive fusariosis are patients with acute leukemia receiving chemotherapeutic regimens for remission induction, and those undergoing allogeneic hematopoietic cell transplant. In this setting,...

Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management

Thompson, G. R., Jenks, J. D., Baddley, J. W., … Hoenigl, M. - 2023 - Clinical Microbiology Reviews, e00019-23

Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (.70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis...

Invasive Scedosporium and Lomentospora prolificans Infections in Australia: A Multicenter Retrospective Cohort Study

Neoh, C. F., Chen, S. C. A., Crowe, A., … Slavin, M. A. - 2023 - Open Forum Infectious Diseases, 10(2), ofad059

Management of Scedosporium/Lomentospora prolificans infections remains challenging. We described predisposing factors, clinical manifestations, and outcomes of these rare mold infections, including predictors of early (1-month) and late (18-month) all-cause mortality and treatment failure.We conducted a retrospective Australian-based observational study of proven/probable Scedosporium/L prolificans infections from 2005 to 2021. Data on patient comorbidities, predisposing factors, clinical...

Invasive fungal infections after respiratory viral infections in lung transplant recipients are associated with lung allograft failure and chronic lung allograft dysfunction within 1 year

Permpalung, N., Liang, T., Gopinath, S., … Shah, P. D. - 2023 - The Journal of Heart and Lung Transplantation, S1053249823000475

Duration of antifungal treatment in mold infection: when is enough?

Portillo, V., & Neofytos, D. - 2023 - Current Opinion in Infectious Diseases, 36(6), 443–449

Decisions to stop antifungal treatment are based on poorly defined treatment responses and immune reconstitution and experts’ opinions. More evidence is needed to determine the optimal duration of treatment of IMI. Well designed, easy to use, and realistic algorithms to help clinicians decide when to stop antifungal treatment are urgently needed.

Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta-analysis

Radcliffe, C., Radcliffe, A. J., Azar, M. M., & Grant, M. - 2022 - Transplant Infectious Disease, 24(2), e13819

Background Dematiaceous fungi cause a number of infectious syndromes referred to as phaeohyphomycosis among both immunocompetent and immunocompromised hosts. We performed a systematic review to characterize these infections in solid organ transplant recipients (SOTR). Methods We searched PubMed database (last searched 1/6/2022) for English-language reports on dematiaceous fungal infections in SOTR. Included reports needed individualized demographic, treatment, and outcome data; pediatric...

Emerging Fungal Infections

Spallone, A., & Schwartz, I. S. - 2021 - Infectious Disease Clinics of North America, 35(2), 261–277

The quest for new antifungal and antitubercular drugs is a need of the hour because of morbid co-pathogenesis and an increase in immunocompromised patients. One of the ways forward is to explore and repurpose the established pharmacophores for the desired application. Oxazolidinones are well-known antibacterial agents, with few investigations reported to exploit their antifungal properties. Herein, we report the design and synthesis of a series of linezolid-based oxazolidinones as potent...

Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology

Hoenigl, M., Salmanton-García, J., Walsh, T. J., … Cornely, O. A. - 2021 - The Lancet Infectious Diseases, 21(8), e246–e257

Non-Aspergillus Fungal Infections in Transplant Patients

Revankar, S. G. - 2021 - In M. I. Morris, C. N. Kotton, & C. Wolfe (Eds.), Emerging Transplant Infections (pp. 1139–1154) - Springer International Publishing

Fungal infections in recipients of solid organ and hematopoietic stem cell transplant recipients are significant causes of morbidity and mortality. Though relatively uncommon compared to other infectious complications, the difficulty in making a timely diagnosis and effectively treating patients presents a daunting challenge. Among the fungi responsible for these infections, there are many that are rarely encountered clinically yet are associated with high mortality in transplant patients....

Invasive Mold Infections After Chimeric Antigen Receptor–Modified T-Cell Therapy: A Case Series, Review of the Literature, and Implications for Prophylaxis

Haidar, G., Dorritie, K., Farah, R., … Samanta, P. - 2020 - Clinical Infectious Diseases, 71(3), 672–676

Data on invasive mold infections (IMIs) after chimeric antigen receptor-modified T-cell (CAR-T-cell) therapy are limited. We describe 2 patients with post–CAR-T-cell IMI (Fusarium, Mucorales) and review the published literature. We propose strategies to prevent IMIs in patients, based on the IMI rate and presence of neutropenia or steroid use.

Emerging fungal infections in solid organ transplant recipients: Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice

Shoham, S., Dominguez, E. A., & Practice, the A. I. D. C. of - 2019 - Clinical Transplantation, 33(9), e13525

These updated AST-IDCOP guidelines review the epidemiology, diagnosis, and management of emerging fungi after organ transplantation. Infections due to numerous generally innocuous fungi are increasingly recognized in solid organ transplant (SOT) recipients, comprising about 7%-10% of fungal infections in this setting. Such infections are collectively referred to as emerging fungal infections and include Mucormycetes, Fusarium, Scedosporium, and dematiaceous fungi among others. The causative...

Dematiaceous Molds

Wong, E. H., & Revankar, S. G. - 2016 - Infectious Disease Clinics of North America, 30(1), 165–178

ESCMID† and ECMM‡ joint clinical guidelines for the diagnosis and management of rare invasive yeast infections

Arendrup, M. C., Boekhout, T., Akova, M., … Lortholary, O. - 2014 - Clinical Microbiology and Infection, 20, 76–98

<h2>Abstract</h2><p>The mortality associated with invasive fungal infections remains high with that involving rare yeast pathogens other than <i>Candida</i> being no exception. This is in part due to the severe underlying conditions typically predisposing patients to these healthcare-related infections (most often severe neutropenia in patients with haematological malignancies), and in part due to the often challenging intrinsic susceptibility pattern of the pathogens that potentially leads...

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi

Chowdhary, A., Meis, J. F., Guarro, J., … Cuenca-Estrella, M. - 2014 - Clinical Microbiology and Infection, 20, 47–75

ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others

Tortorano, A. M., Richardson, M., Roilides, E., … Lass-Flörl, C. - 2014 - Clinical Microbiology and Infection, 20, 27–46

Histopathologic Diagnosis of Fungal Infections in the 21st Century

Guarner, J., & Brandt, M. E. - 2011 - Clinical Microbiology Reviews, 24(2), 247–280

Summary: Fungal infections are becoming more frequent because of expansion of at-risk populations and the use of treatment modalities that permit longer survival of these patients. Because histopathologic examination of tissues detects fungal invasion of tissues and vessels as well as the host reaction to the fungus, it is and will remain an important tool to define the diagnostic significance of positive culture isolates or results from PCR testing. However, there are very few instances...

Melanized Fungi in Human Disease

Revankar, S. G., & Sutton, D. A. - 2010 - Clinical Microbiology Reviews, 23(4), 884–928

Summary: Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes. Many are soil organisms and are generally distributed worldwide, though certain species appear to have restricted geographic ranges. Though they are uncommon causes of disease, melanized fungi have been increasingly recognized as important pathogens, with most reports occurring in the past 20 years. The spectrum of diseases with which they are associated has also broadened and includes...

Clinical Practice Guidelines for the Management of Sporotrichosis: 2007 Update by the Infectious Diseases Society of America

Kauffman, C. A., Bustamante, B., Chapman, S. W., & Pappas, P. G. - 2007 - Clinical Infectious Diseases, 45(10), 1255–1265

Guidelines for the management of patients with sporotrichosis were prepared by an Expert Panel of the Infectious Diseases Society of America and replace the guidelines published in 2000. The guidelines are intended for use by internists, pediatricians, family practitioners, and dermatologists. They include evidence-based recommendations for the management of patients with lymphocutaneous, cutaneous, pulmonary, osteoarticular, meningeal, and disseminated sporotrichosis. Recommendations are...

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