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Direct T-cell Inhibition and Agents Targeting T-cell Migration and Chemotaxis

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Resource type
Journal Article
Authors/contributors
Title
Direct T-cell Inhibition and Agents Targeting T-cell Migration and Chemotaxis
Abstract
Lymphocyte depletion and blockade of T-cell activation and trafficking serve as therapeutic strategies for an enlarging number of immune-mediated diseases and malignancies. This review summarizes the infection risks associated to monoclonal antibodies that bind to the α chain of the interleukin-2 receptor, the cell surface glycoprotein CD52, and members of α4- and β2-integrin families acting as cell-adhesion molecules. An outline of the mechanisms of action, approved indications and off-label uses, expected impact on the host immune response, and available clinical evidence is provided for each of these agents.
Publication
Infectious Disease Clinics
Date
2020/06/01
Volume
34
Issue
2
Pages
191-210
Journal Abbr
Infectious Disease Clinics
DOI
10.1016/j.idc.2020.02.002
URL
https://www.id.theclinics.com/article/S0891-5520(20)30004-0/abstract
Accessed
9/1/21, 3:43 PM
ISSN
0891-5520, 1557-9824
Language
English
Library Catalog
www.id.theclinics.com
Extra
Publisher: Elsevier PMID: 32334982
Citation
Fernández-Ruiz, M., & Aguado, J. M. (2020). Direct T-cell Inhibition and Agents Targeting T-cell Migration and Chemotaxis. Infectious Disease Clinics, 34(2), 191–210. https://doi.org/10.1016/j.idc.2020.02.002
HEME-ONC AND CELLULAR THERAPIES
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https://www.transplantid.net/9NTEQLHX