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Synonyms African histoplasmosis. Contrast with North American histoplasmosis due to Histoplasma capsulatum Definition and forms of the disease Histoplasmosis due to N/A(L):Histoplasma duboisii is a mycotic infection primarily involving cutaneous, liver, lung, lymphatic, subcutaneous, and bony tissues. Skin and bone are the most frequently invaded sites [454]. The etiologic agent grows as a large yeast within giant cells. It may also present with small cells that are typical of those seen in histoplasmosis due to Histoplasma capsulatum. Nodular and ulcerative cutaneous and osteolytic lesions of bone that disseminate or remain localized are the primary clinical characteristics of histoplasmosis duboisii [11, […]