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Management of Other Toxicities
Resource type
Book Section
Authors/contributors
- Einsele, Hermann (Author)
- Yakoub-Agha, Ibrahim (Author)
- Kröger, Nicolaus (Editor)
- Gribben, John (Editor)
- Chabannon, Christian (Editor)
- Yakoub-Agha, Ibrahim (Editor)
- Einsele, Hermann (Editor)
Title
Management of Other Toxicities
Abstract
Secondary haemophagocytic lymphohistiocytosis (sHLH) or macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory syndrome that can occur in patients with severe infections, e.g., COVID-19 infection, malignancy or autoimmune diseases. It is also a rare complication of allogeneic haematopoietic cell transplantation (allo-HCT), independent of the underlying trigger mechanism or underlying disorders associated with high mortality. There have been increasing reports of sHLH/MAS occurrence following CAR-T cell therapy, but its differentiation from cytokine release syndrome (CRS) is often difficult (Sandler et al. 2020).
Book Title
The EBMT/EHA CAR-T Cell Handbook
Date
2022
Publisher
Springer International Publishing
Place
Cham
Pages
157-160
ISBN
978-3-030-94353-0
Accessed
6/26/22, 4:47 PM
Language
en
Library Catalog
Springer Link
Extra
Citation
Einsele, H., & Yakoub-Agha, I. (2022). Management of Other Toxicities. In N. Kröger, J. Gribben, C. Chabannon, I. Yakoub-Agha, & H. Einsele (Eds.), The EBMT/EHA CAR-T Cell Handbook (pp. 157–160). Springer International Publishing. https://doi.org/10.1007/978-3-030-94353-0_30
TEXTBOOKS
HEME-ONC AND CELLULAR THERAPIES
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