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Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management
Resource type
Book Section
Authors/contributors
- Morris, Michele I. (Editor)
- Kotton, Camille Nelson (Editor)
- Wolfe, Camille (Editor)
- Malinis, Maricar (Author)
- Azar, Marwan M. (Author)
Title
Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management
Abstract
Infections due to adenoviruses confer significant morbidity and mortality in immunocompromised hosts. Manifestations of disease in the setting of hematopoietic stem cell and solid organ transplantation may range from asymptomatic shedding or viremia to localized infection and disseminated disease. In solid organ transplant recipients, adenoviral disease often involves the allograft and can lead to graft dysfunction and/or graft loss. Several diagnostic methods are available for adenovirus infections, which include viral culture, direct antigen detection, molecular techniques, and histopathology. The cornerstone of treatment is the reduction of immunosuppression. Adjunct antiviral therapy is used if there is an inadequate clinical response to immunosuppression reduction. Immunotherapy is an option for those who fail to respond to established therapeutic options.
Book Title
Emerging Transplant Infections
Date
2021
Publisher
Springer International Publishing
Place
Cham
Pages
781-806
ISBN
978-3-030-01751-4
Accessed
10/23/21, 9:34 AM
Short Title
Transplant Adenovirus Infection
Language
en
Library Catalog
DOI.org (Crossref)
Extra
Citation
Malinis, M., & Azar, M. M. (2021). Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management. In M. I. Morris, C. N. Kotton, & C. Wolfe (Eds.), Emerging Transplant Infections (pp. 781–806). Springer International Publishing. https://doi.org/10.1007/978-3-030-01751-4_33-1
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