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Challenges in the Treatment of Invasive Aspergillosis in Immunocompromised Children
Resource type
Journal Article
Authors/contributors
- Hsu, Alice J. (Author)
- Tamma, Pranita D. (Author)
- Fisher, Brian T. (Author)
Title
Challenges in the Treatment of Invasive Aspergillosis in Immunocompromised Children
Abstract
Invasive aspergillosis (IA) is associated with significant morbidity and mortality. Voriconazole remains the drug of choice for the treatment of IA in children; however, the complex kinetics of voriconazole in children make dosing challenging and therapeutic drug monitoring (TDM) essential for treatment success. The overarching goal of this review is to discuss the role of voriconazole, posaconazole, isavuconazole, liposomal amphotericin B, echinocandins, and combination antifungal therapy for the treatment of IA in children. We also provide a detailed discussion of antifungal TDM in children.
Publication
Antimicrobial Agents and Chemotherapy
Date
2022-06-29
Pages
e02156-21
Journal Abbr
Antimicrob Agents Chemother
Accessed
7/9/22, 7:07 AM
ISSN
0066-4804, 1098-6596
Language
en
Library Catalog
DOI.org (Crossref)
Citation
Hsu, A. J., Tamma, P. D., & Fisher, B. T. (2022). Challenges in the Treatment of Invasive Aspergillosis in Immunocompromised Children. Antimicrobial Agents and Chemotherapy, e02156-21. https://doi.org/10.1128/aac.02156-21
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