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Infectious Implications of Interleukin-1, Interleukin-6, and T Helper Type 2 Inhibition

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Resource type
Journal Article
Author/contributor
Title
Infectious Implications of Interleukin-1, Interleukin-6, and T Helper Type 2 Inhibition
Abstract
Targeting interleukins that drive innate inflammation has expanded treatments of autoinflammatory and autoimmune disorders. Interleukin (IL)-1 inhibition has proven useful for monogenic autoinflammatory syndromes, and IL-6 inhibition for autoimmune arthritides. Biological therapies impeding these pathways impair detection and containment of pathogens, particularly invasive bacteria, reflecting the importance of IL-1 and IL-6 in communicating danger throughout the immune system. Biologics targeting T helper type 2 inflammation are used to treat specific allergic, atopic, and eosinophilic diseases. They may impair protections against local herpesvirus reactivations while augmenting antiviral responses to respiratory viruses. Their risks with helminth exposures have yet to be defined.
Publication
Infectious Disease Clinics
Date
2020/06/01
Volume
34
Issue
2
Pages
211-234
Journal Abbr
Infectious Disease Clinics
DOI
10.1016/j.idc.2020.02.003
URL
https://www.id.theclinics.com/article/S0891-5520(20)30005-2/abstract
Accessed
9/1/21, 3:43 PM
ISSN
0891-5520, 1557-9824
Language
English
Library Catalog
www.id.theclinics.com
Extra
Publisher: Elsevier PMID: 32334983
Citation
Liu, A. Y. (2020). Infectious Implications of Interleukin-1, Interleukin-6, and T Helper Type 2 Inhibition. Infectious Disease Clinics, 34(2), 211–234. https://doi.org/10.1016/j.idc.2020.02.003
HEME-ONC AND CELLULAR THERAPIES
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https://www.transplantid.net/XEMKHCYZ